Biased hypermutagenesis associated with mutations in an untranslated hairpin of an RNA virus.
نویسندگان
چکیده
The mutation frequency of Turnip crinkle virus can increase 12-fold without inducing error catastrophe. Lesions in a hairpin repressor frequently reverted and led to second-site alterations biased for specific mutations. These results suggest that the hairpin may also function as an RNA chaperone to properly fold the RNA-dependent RNA polymerase.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of virology
دوره 78 14 شماره
صفحات -
تاریخ انتشار 2004